MACC1 as a marker for advanced colorectal carcinoma.
نویسندگان
چکیده
BACKGROUND Recently, Stein et al. identified the metastasis-associated in colon cancer 1 (MACC1) gene by genome-wide search for differentially expressed genes in human colon cancer tissues and metastases. PATIENTS AND METHODS We analyzed MACC1 expression levels in 52 colorectal cancer samples using quantitative real-time polymerase chain reaction (QRT-PCR). RESULTS We found that MACC1 expression showed significant correlation with peritoneal dissemination (p=0.042) and higher stage of TNM classification (p=0.007). CONCLUSION These results suggest that MACC1 is more frequently expressed in advanced colorectal carcinomas.
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ورودعنوان ژورنال:
- Anticancer research
دوره 30 7 شماره
صفحات -
تاریخ انتشار 2010